MCQs in Fats and fatty acid metabolism

 

1. An example of a hydroxy fatty acid is

(A) Ricinoleic acid (C) Butyric acid	(B) Crotonic acid (D) Oleic acid
2. An example of a saturated fatty acid is
(A) Palmitic acid (C) Linoleic acid	(B) Oleic acid (D) Erucic acid

3. If the fatty acid is esterified with an alcohol of high molecular weight instead of glycerol, the resulting compound is

(A) Lipositol (C) Wax	(B) Plasmalogen (D) Cephalin
4. A fatty acid which is not synthesized in the body and has to be supplied in the
diet is (A) Palmitic acid (C) Linolenic acid	(B) Lauric acid (D) Palmitoleic acid

5. Essential fatty acid:

(A) Linoleic acid	(B) Linolenic acid
(C) Arachidonic acid (D) All these 6. The fatty acid present in cerebrosides is
(A) Lignoceric acid	(B) Valeric acid

(C) Caprylic acid	(D) Behenic acid
7. The number of double bonds in arachi
donic acid is (A) 1 (C) 4	(B) 2 (D) 6

8. In humans, a dietary essential fatty acid is

(A) Palmitic acid (C) Oleic acid

(B) Stearic acid (D) Linoleic acid

9. A lipid containing alcoholic amine residue is
(A) Phosphatidic acid                            (B) Ganglioside
(C) Glucocerebroside                            (D) Sphingomyelin
10. Cephalin consists of
(A) Glycerol, fatty acids, phosphoric acid and choline
(B) Glycerol, fatty acids, phosphoric acid and ethanolamine
(C) Glycerol, fatty acids, phosphoric acid and inositol
(D) Glycerol, fatty acids, phosphoric acid and serine

11. In mammals, the major fat in adipose tissues is

(A) Phospholipid (C) Sphingolipids

(B) Cholesterol (D) Triacylglycerol

12. Glycosphingolipids are a combination of
(A) Ceramide with one or more sugar residues
(B) Glycerol with galactose
(C) Sphingosine with galactose
(D) Sphingosine with phosphoric acid

13. The importance of phospholipids as constituent of cell membrane is because
they possess
(A) Fatty acids
(B) Both polar and nonpolar groups
(C) Glycerol
(D) Phosphoric acid
14. In neutral fats, the unsaponificable matter includes

(A) Hydrocarbons (C) Phospholipids	(B) Triacylglycerol (D) Cholsesterol
15. Higher alcohol present in waxes is
(A) Benzyl (C) Ethyl	(B) Methyl (D) Cetyl

16. Kerasin consists of

(A) Nervonic acid (C) Cervonic acid	(B) Lignoceric acid (D) Clupanodonic acid
17. Gangliosides are complex glycosphin
golipids found in (A) Liver (C) Kidney	(B) Brain (D) Muscle

18. Unsaturated fatty acid found in the cod liver oil and containing 5 double bonds is
(A) Clupanodonic acid
(B) Cervonic acid
(C) Elaidic acid
(D) Timnodonic acid
19. Phospholipid acting as surfactant is

(A) Cephalin (C) Lecithin	(B) Phosphatidyl inositol (D) Phosphatidyl serine
20. An oil which contains cyclic fatty acids and once used in the treatment of leprosy is
(A) Elaidic oil	(B) Rapeseed oil

(C) Lanoline	(D) Chaulmoogric oil
21. Unpleasant odours and taste in a fa (rancidity) can be delayed or prevented
by the addition of (A) Lead (C) Tocopherol	(B) Copper (D) Ergosterol

22. Gangliosides derived from glucosylceramide contain in addition one or more
molecules of

(A) Sialic acid (C) Diacylglycerol

(B) Glycerol (D) Hyaluronic acid

23. ’Drying oil’, oxidized spontaneously by atmospheric oxygen at ordinary temperature and forms a hard water proof material is

(A) Coconut oil (C) Rape seed oil

(B) Peanut oil (D) Linseed oil

24. Deterioration of food (rancidity) is due to presence of
(A) Cholesterol
(B) Vitamin E
(C) Peroxidation of lipids
(D) Phenolic compounds
25. The number of ml of N/10 KOH required to neutralize the fatty acids in the distillate from 5 gm of fat is called
(A) Reichert-Meissel number
(B) Polenske number
(C) Acetyl number
(D) Non volatile fatty acid number
26. Molecular formula of cholesterol is
(A) C27H45OH
(B) C29H47OH
(C) C29H47OH
(D) C23H41OH
27. The cholesterol molecule is
(A) Benzene derivative
(B) Quinoline derivative
(C) Steroid
(D) Straight chain acid
28. Salkowski test is performed to detect

(A) Glycerol (C) Fatty acids	(B) Cholesterol (D) Vitamin D
29. Palmitic, oleic or stearic acid ester of cholesterol used in manufacture of
cosmetic creams is (A) Elaidic oil (C) Spermaceti	(B) Lanoline (D) Chaulmoogric oil

30. Dietary fats after absorption appear in the circulation as

(A) HDL (C) LDL

(B) VLDL (D) Chylomicron

31. Free fatty acids are transported in the blood
(A) Combined with albumin
(B) Combined with fatty acid binding protein
(C) Combined with β -lipoprotein
(D) In unbound free salts
32. Long chain fatty acids are first activated to acetyl-CoA in

(A) Cytosol (C) Nucleus	(B) Microsomes (D) Mitochondria
33. The enzyme acyl-CoA synthase catalyses the conversion of a fatty acid of an active fatty acid in the presence of
(A) AMP (C) ATP	(B) ADP (D) GTP

34. Carnitine is synthesized from
(A) Lysine and methionine
(B) Glycine and arginine
(C) Aspartate and glutamate
(D) Proline and hydroxyproline
35. The enzymes of β-oxidation are found in
(A) Mitochondria (B) Cytosol
(C) Golgi apparatus (D) Nucleus
36. Long chain fatty acids penetrate the inner mitochondrial membrane
(A) Freely
(B) As acyl-CoA derivative
(C) As carnitine derivative
(D) Requiring Na dependent carrier
37. An important feature of Zellweger’s syndrome is
(A) Hypoglycemia
(B) Accumulation of phytanic acid in tissues
(C) Skin eruptions
(D) Accumulation of C26-C38 polyenoic acid in
brain tissues
38. An important finding of Fabry’s disease is
(A) Skin rash (B) Exophthalmos
(C) Hemolytic anemia (D) Mental retardation
39. Gaucher’s disease is due to deficiency of the enzyme:
(A) Sphingomyelinase
(B) Glucocerebrosidase
(C) Galactocerbrosidase
(D) β-Galactosidase
40. Characteristic finding in Gaucher’s disease is
(A) Night blindness
(B) Renal failure
(C) Hepatosplenomegaly
(D) Deafness
41. An important finding in Neimann-Pick disease is
(A) Leukopenia
(B) Cardiac enlargement
(C) Corneal opacity
(D) Hepatosplenomegaly
42. Fucosidosis is characterized by
(A) Muscle spasticity (B) Liver enlargement

(C) Skin rash	(D) Kidney failure
43. Metachromatic leukodystrophy is due to deficiency of enzyme:
(A) α-Fucosidase (C) Ceramidase	(B) Arylsulphatase A (D) Hexosaminidase A

44. A significant feature of Tangier disease is
(A) Impairment of chylomicron formation
(B) Hypotriacylglycerolmia
(C) Absence of Apo-C-II
(D) Absence of Apo-C-I
45. A significant feature of Broad Beta disease is
(A) Hypocholesterolemia
(B) Hypotriacylglycerolemia
(C) Absence of Apo-D
(D) Abnormality of Apo-E

46. Neonatal tyrosinemia improves on administration of

(A) Thiamin (C) Pyridoxine

(B) Riboflavin (D) Ascorbic acid

47. Absence of phenylalanine hydroxylase causes
(A) Neonatal tyrosinemia
(B) Phenylketonuria
(C) Primary hyperoxaluria
(D) Albinism
48. Richner-Hanhart syndrome is due to defect in
(A) Tyrosinase
(B) Phenylalanine hydroxylase
(C) Hepatic tyrosine transaminase
(D) Fumarylacetoacetate hydrolase
49. Plasma tyrosine level in Richner-Hanhart syndrome is

(A) 1–2 mg/dL (C) 4–5 mg/dL

(B) 2–3 mg/dL (D) 8–10 mg/dL

50. Amount of phenylacetic acid excreted in the urine in phenylketonuria is
(A) 100–200 mg/dL (B) 200–280 mg/dL
(C) 290–550 mg/dL (D) 600–750 mg/dL
51. Tyrosinosis is due to defect in the enzyme:
(A) Fumarylacetoacetate hydrolase
(B) p-Hydroxyphenylpyruvate hydroxylase
(C) Tyrosine transaminase
(D) Tyrosine hydroxylase
52. An important finding in Histidinemia is
(A) Impairment of conversion of α-Glutamate to α-ketoglutarate
(B) Speech defect
(C) Decreased urinary histidine level
(D) Patients can not be treated by diet
53. An important finding in glycinuria is
(A) Excess excretion of oxalate in the urine
(B) Deficiency of enzyme glycinase
(C) Significantly increased serum glycine level
(D) Defect in renal tubular reabsorption of glycine
54. Increased urinary indole acetic acid is diagnostic of
(A) Maple syrup urine disease
(B) Hartnup disease
(C) Homocystinuia
(D) Phenylketonuria
55. In glycinuria daily urinary excretion of glycine ranges from

(A) 100–200 mg (C) 600–1000 mg

(B) 300–500 mg (D) 1100–1400 mg

56. An inborn error, maple syrup urine disease is due to deficiency of the enzyme:
(A) Isovaleryl-CoAhydrogenase
(B) Phenylalnine hydroxylase
(C) Adenosyl transferase
(D) α-Ketoacid decarboxylase
57. Maple syrup urine disease becomes evident in extra uterine life by the end of

(A) First week (C) Third week

(B) Second week (D) Fourth week

58. Alkaptonuria occurs due to deficiency of the enzyme:
(A) Maleylacetoacetate isomerase
(B) Homogentisate oxidase
(C) p-Hydroxyphenylpyruvate hydroxylase
(D) Fumarylacetoacetate hydrolase
59. An important feature of maple syrup urine disease is
(A) Patient can not be treated by dietary regulation
(B) Without treatment death, of patient may occur by the end of second year of life
(C) Blood levels of leucine, isoleucine and serine are increased
(D) Excessive brain damage
60. Ochronosis is an important finding of
(A) Tyrosinemia
(B) Tyrosinosis
(C) Alkaptonuria
(D) Richner Hanhart syndrome

Answer Key:

1. A 2. A 3. C 4. C 5. D 6. A 7. C 8. D 9. D 10. B 11. D 12. A 13. B 14. A 15. D 16. B 17. B 18. D 19. C 20. D 21. C 22. A 23. D 24. C 25. A 26. A 27. C 28. B 29. B 30. D 31. A 32. A 33. C 34. A 35. A 36. C 37. D 38. A 39. B 40. C 41. D 42. A 43. B 44. C 45. D 46. A 47. D 48. B 49. C 50. C 51. A 52. B 53. D 54. B 55. C 56. D 57. A 58. B 59. D 60. C